Humanization of immunotoxins.
نویسندگان
چکیده
منابع مشابه
Humanization of antibodies.
Humanization has played a fundamental role in the remarkable progress of antibodies as therapeutic reagents. Here we have reviewed the publications on antibody humanization since the first report on CDR grafting in the second half of the 1980's up to June 2007. We describe the two main trends in the field: rational and empirical methods to humanize antibodies. Rational methods rely on the so-ca...
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The article by Salvatore et al. (1) in this issue of Clinical Cancer Research describes the synthesis and biological activity of an improved, recombinant immunotoxin targeted to the CD22 B-cell antigen. This particularly well-performed study is one of a large series of significant innovations in the field by this and other groups of investigators in the last few years. To appreciate more fully ...
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متن کاملThe future of antiviral immunotoxins.
There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments. Immunotoxins have been extensively explored in cancer treatment and have achieved FDA approval in several cases. Indeed, the design of new anticancer immunotoxins is a rapidly developing field. Howe...
متن کاملAntibody Humanization Techniques
Antibodies are proteins with very important functions in the immune system. Thanks to their ability to recognize specific sequences from pathogens and other threats, antibodies can participate in the recognition and removal of foreign threats, such as virus and bacteria (Janeway et al.). Every human body is able to create millions of slightly different antibodies; every antibody has the ability...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1992
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.89.8.3165